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|Sibutramine (top), ( S )-(−)-sibutramine (bottom)|
|Trade names||Meridia, others|
|Pregnancy category||AU: C US: C (Risk not ruled out) No human data exists; inconclusive evidence of teratogenic potential in animal studies|
|Routes of administration||Oral (capsules)|
|ATC code||A08AA10 ( WHO )|
|Legal status||US: Schedule IV|
|Bioavailability||Absorption 77%, considerable first-pass metabolism|
|Protein binding||97%, (94% for its desmethyl metabolites, M 1 & M 2 )|
|Elimination half-life||1 hour (sibutramine), 14 hours (M 1 ) & 16 hours (M 2 )|
|Excretion||Urine (77%), feces (8%)|
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The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse sibutramine metabolites, nor should it be construed to indicate that use of a particular drug is safe, appropriate or sibutramine metabolite for you or sibutramine metabolite else.
A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.MERIDIA should be given with caution to those patients with a history of hypertension, and should not be given to patients with uncontrolled or poorly controlled hypertension.
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