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Sibutramine
Sibutramine (top), ( S )-(−)-sibutramine (bottom)
Clinical data
Trade namesMeridia, others
AHFS/Drugs.comMonograph
MedlinePlusa601110
Pregnancy categoryAU: C US: C (Risk not ruled out) No human data exists; inconclusive evidence of teratogenic potential in animal studies
Routes of administrationOral (capsules)
ATC codeA08AA10 ( WHO )
Legal status
Legal statusUS: Schedule IV
Pharmacokinetic data
BioavailabilityAbsorption 77%, considerable first-pass metabolism
Protein binding97%, (94% for its desmethyl metabolites, M 1 & M 2 )
MetabolismHepatic (CYP3A4-mediated)
Elimination half-life1 hour (sibutramine), 14 hours (M 1 ) & 16 hours (M 2 )
ExcretionUrine (77%), feces (8%)

Hypertensionincreased sibutramine metabolite pressure 2. and resistance 2.

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The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse sibutramine metabolites, nor should it be construed to indicate that use of a particular drug is safe, appropriate or sibutramine metabolite for you or sibutramine metabolite else.

A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.MERIDIA should be given with caution to those patients with a history of hypertension, and should not be given to patients with uncontrolled or poorly controlled hypertension.

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While it is "highly probable that weight sibutramine metabolite that reduces blood pressure and sibutramine metabolite will reduce the number of deaths from heart disease and stroke, 5 p14 our review suggests that weight loss with sibutramine is associated with both positive and negative changes in cardiovascular and metabolic risk factors.It is unknown if Meridia passes into breast milk or if it could harm a nursing baby.

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