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COMMIT included 45, 52 patients presenting clopidogrel constipation 24 hours of the clopidogrel constipation of the symptoms of myocardial infarction with supporting ECG abnormalities i. ST-elevation, ST-depression or left bundle-branch block Patients were randomized to receive clopidogrel bisulfate 75 mg once daily or placebo, in combination with aspirin 162 mg per day for 28 days or until hospital discharge, whichever came first.vs or homesite.

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These results, as well as other findings, encouraged the United States US Food and Drug Administration FDA to issue labelled warning on clopidogrel box recommending the genotyping of CYP2C19 in order to prevent recurrence of cardiovascular events12.Our study included any randomized controlled trial or observational study that reported at clopidogrel constipation one of the following outcomes: major adverse cardiovascular event MACE; a composite outcome typically comprised of myocardial clopidogrel constipation, stroke, and/or cardiovascular death cardiovascular CV gastrointestinal GI bleed.

Studies were excluded if they were composed of non-PCI patients, if there was no PCI subgroup analysis, or if there was not at least a 6-month follow-up period to avoid studies focusing on short term or evaluated but not used as exclusion criteria.

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