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These results, as well as other findings, encouraged the United States US Food and Drug Administration FDA to issue labelled warning on clopidogrel box recommending the genotyping of CYP2C19 in order to prevent recurrence of cardiovascular events12.Our study included any randomized controlled trial or observational study that reported at clopidogrel constipation one of the following outcomes: major adverse cardiovascular event MACE; a composite outcome typically comprised of myocardial clopidogrel constipation, stroke, and/or cardiovascular death cardiovascular CV gastrointestinal GI bleed.
Studies were excluded if they were composed of non-PCI patients, if there was no PCI subgroup analysis, or if there was not at least a 6-month follow-up period to avoid studies focusing on short term or evaluated but not used as exclusion criteria.
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