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Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may depo medrol methylprednisolone aggravated by corticosteroids.Corticosteroids may mask some signs of current infection.

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All depo medrol methylprednisolone acetates increase calcium excretion – Literature reports suggest an apparent association between the use of corticosteroids and left ventricular free wall rupture after a recent myocardial infarction; therefore, therapy with corticosteroids should be used with great caution in these patients.Shake this medication well before using.


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