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|Pronunciation||Paracetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ( listen )|
|Trade names||Tylenol, Panadol, others |
|License data||US FDA: Acetaminophen|
|Pregnancy category||AU: A US: C (Risk not ruled out)  Not tested but seems to be safe|
|Routes of administration||By mouth, through the cheek, rectal, intravenous (IV)|
|ATC code||N02BE01 ( WHO )|
|Legal status||AU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC|
|Bioavailability||63–89%  : 73|
|Protein binding||10–25% |
|Metabolism||Predominantly in the liver |
|Metabolites||APAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI |
|Onset of action||Pain relief onset by route: By mouth – 37 minutes  Buccal – 15 minutes  Intravenous – 8 minutes |
|Elimination half-life||1–4 hours |
|Excretion||Urine (85–90%) |
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Those with evidence of increased intracranial pressure or brain tumors acetaminophen and codeine phosphate oral solution may reduce respiratory drive, and the resultant CO 2 retention can further increase intracranial pressure.ylenol Regular Strength acetaminophen doesn t treat some kinds of pain as well as other medications like Advil.
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A reduction in the number of white blood cells has also been reported.If AST and alanine transaminases ALT are elevated, it should be assumed that the patient is in the second stage of acetaminophen toxicity and acetylcysteine therapy should be initiated.
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