Consider: The Effects Of Prenatal Tobacco Exposure On
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Methamphetamine use among pregnant women is an increasing problem in the United States. Effects of methamphetamine use during pregnancy on fetal growth have not been reported in large, prospective studies. We examined the neonatal growth effects of prenatal methamphetamine exposure in the multicenter, longitudinal Infant Development, Environment and Lifestyle study.
The Infant Development, Environment and Lifestyle study screened subjects at 4 clinical centers: were eligible and consented, among which 84 were methamphetamine exposed, and were unexposed. Those who were unexposed denied amphetamine use and had a negative Tobacoc screen. Both groups included prenatal alcohol, tobacco, or marijuana use, but excluded use of opiates, LSD, PCP or cocaine only.
Neonatal parameters included birth weight and gestational age in weeks. One-way analysis of variance and linear-regression analyses were conducted on birth weight by exposure.
مطالعه توسعه، محیط، و شیوه زندگی نوزاد: اثرات of، نوردهی، و فقر بر رشد اقتصادی
The relationship of methamphetamine exposure and the incidence of small for gestational age was analyzed using multivariate logistic-regression analyses. The methamphetamine exposed group was 3.
Mothers who used tobacco during pregnancy were nearly 2 times more likely to have small-for-gestational-age infants. In addition, less maternal weight gain during pregnancy was more likely to result in a small-for-gestational-age infant.
Birthweight in the methamphetamine exposed group was lower than the unexposed group. These findings suggest that prenatal methamphetamine use is associated with fetal growth restriction after adjusting for covariates. Continued follow-up will determine if these infants are at increased risk for growth abnormalities in the future.]