The Effects Of Statins And Its Effect - valuableStatins , drugs prescribed to lower cholesterol and reduce the risk of heart attacks and strokes, are taken by almost eight million people in the UK. However, despite their effectiveness, as many as a fifth of people stop taking statins due to debilitating side-effects, including fatigue, muscle aches, joint pain and nausea. For the first time, patients were able to see for themselves that statins did not cause their side-effects but the physical act of taking a pill did. The study shows the phenomenon occurs when people anticipate experiencing negative symptoms — even if the drug is a placebo. After resuming treatment, the volunteers were given four bottles each atorvastatin, identical-looking placebo pills and four empty bottles, to be taken in a randomly-prescribed order over 12 months. They daily recorded any side-effects on their smartphones, ranking their intensity from zero to The scientists discovered 90 percent of symptoms experienced by the patients occurred after the placebo tablets were taken. And in addition, 24 patients stopped taking tablets for a minimum of a month during the trial, after complaining of intolerable side-effects — amounting to 71 stoppages. A total of 31 of these stoppages took place during placebo months, while 40 were during statin months.
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Statins are one of the most widely prescribed drugs in the UK, taken by nearly eight million people to reduce their risk of cardiovascular disease by lowering cholesterol levels.
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Yet, despite their effectivenessup to a fifth of people stop taking them because of side-effects, such as fatigue, muscle aches, joint pain and nausea. Clinical studies have suggested, however, the incidence of side-effects is far lower. Researchers led by Frances Wood and Dr James Howard at Imperial College London recruited 60 patients who had been on statins, but stopped taking them owing to adverse effects. They were persuaded to resume treatment, and given four bottles containing atorvastatin, four bottles containing identical-looking placebo pills and four empty bottles, to be taken in a randomly https://soundofliberation.com/essay/gibbs-reflective-cycle-1988/a-scenario-of-monitoring-health-condition-of.php order over the course of a year — including four months taking no pills.
Each day, they recorded any side-effects on a smartphone, ranking their intensity from zero to Also, 24 patients stopped taking tablets for at least one month of the trial, citing intolerable side-effects — amounting to 71 stoppages in total. Of these, 31 occurred during placebo months and 40 were during statin months. The results were published in the New England Journal of Medicine. Six months later, 30 of the study participants had restarted statin Statine and Pest Croatia planned to do so. Even so, it is unclear how widely the results can be applied, said Kevin McConway, emeritus professor of applied statistics at the Open University.
In the UK, statins are estimated to prevent 80, heart attacks and strokes each year. The team is now planning a study to investigate symptoms associated with beta-blocker drugs in heart failure patients.
Negative expectations may play part, with adverse effects reported when taking placebo. Linda Geddes. Sun 15 Nov The Faraday cage: from Victorian experiment to Snowden-era paranoia.
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