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|(2 R,4 S )-(+)-ketoconazole (top) (2 S,4 R )-(−)-ketoconazole (bottom)|
|Pronunciation||/ ˌ k iː t oʊ ˈ k oʊ n ə ˌ z oʊ l, - z ɒ l /  |
|Trade names||Nizoral, others|
|License data||EU EMA: by INN, US FDA: Ketoconazole|
|Pregnancy category||AU: B3 US: C (Risk not ruled out)|
|Routes of administration||Oral (tablets), topical (cream, shampoo, solution)|
|ATC code||J02AB02 ( WHO ) D01AC08 ( WHO ) G01AF11 ( WHO )|
|Legal status||UK: OTC US: OTC|
|Bioavailability||Oral: 37–97% |
|Protein binding||84 to 99%|
|Metabolism||Extensive liver (predominantly oxidation, O -dealkylation)|
|Metabolites||N -deacetyl ketoconazole|
|Excretion||Biliary (major) and kidney |
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